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Friday, May 22, 2020 | History

1 edition of Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees found in the catalog.

Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees

Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees

a rapid and systematic review

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Published by Core Research on behalf of the NCCHTA in Alton .
Written in English


Edition Notes

Includes bibliographical references.

StatementP. Jobanputra ... [et al.].
SeriesHealth technology assessment -- v.5, no.11
ContributionsJobanputra, P., National Co-ordinating Centre for HTA (Great Britain)
The Physical Object
Paginationiv, 57p. :
Number of Pages57
ID Numbers
Open LibraryOL19672139M

Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. ;(14) Minas T, Von Keudell A, Bryant T, Gomoll AH. The John Insall Award: A Minimum year Outcome Study of Autologous Chondrocyte Implantation. Mats Brittberg, in Cartilage Surgery, Introduction. Autologous chondrocyte implantation (ACI) is another means of repairing damaged cartilage. 1 It is based on harvest of to mg of cartilage from a less loaded area in the knee. The cartilage is sent to a lab for processing. The cartilage is digested; the isolated chondrocytes are expanded in vitro during 2 to 3 weeks.

In , a further systematic review published by the National Coordinating Centre for Health Technology Assessment 3 x 3 Jobanputra, P., Parry, D., Fry-Smith, A., and Burls, A. Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: a rapid and systematic review. by: Background & objectives: Articular cartilage defects in the knee have a very poor capacity for repair due to avascularity. Autologous chondrocyte transplantation (ACT) is an established treatment.

Jobanputra P, Parry D, Fry-Smith A, Burls A. Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: a rapid and systematic review. Health Technol Assess Cited by: Autologous mesenchymal stem cell transplantation. Because mesenchymal stem cells may regenerate cartilage, cartilage growth in human knees using autologous cultured mesenchymal stem cells is under research and preliminary clinical use, and appears to be safe as of An advantage to this approach is that a person's own stem cells are used, avoiding tissue rejection by the immune Specialty: orthopedic.


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Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees Download PDF EPUB FB2

PDF | On Feb 1,P Jobanputra and others published Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: A rapid and systematic review |. Autologous chondrocyte implantation (ACI) is a surgical approach used to treat full-thickness cartilage defects in knee joints.

Small samples of normal cartilage with the cells that produce the cartilage (chondrocytes) are removed from the damaged by: Objective: To support a review of the guidance issued by the National Institute for Health and Clinical Excellence (NICE) in December by examining the current clinical and cost-effectiveness evidence on autologous cartilage transplantation.

Data sources: Electronic databases. Review methods: Evidence on clinical effectiveness was obtained from randomised trials, supplemented by data from Cited by: Autologous chondrocyte implantation involves laboratory culture of cartilage-producing cells from the knee and then implanting them into the chondral defect.

Objective: To assess the clinical effectiveness and cost-effectiveness of ACI in chondral defects in the knee, compared with microfracture (MF).Cited by: Autologous chondrocyte implantation (ACI) is a surgical approach used to treat full-thickness cartilage defects in knee joints.

Small samples of normal cartilage with the cells that produce the cartilage (chondrocytes) are removed from the damaged joint. The cells are cultured in special laboratories to increase the number of cells and reimplanted a few weeks later into the areas of cartilage damage.

" Autologous chondrocyte transplantation for cartilage defects in the knee joint " [3]. Hyaline cartilage damage is not clear and the natural history is poorly understood.

autologous chondrocyte transplantation, have been tested in controlled studies. This report is based on studies of patient cohorts with hyaline cartilage defects. These studies indicate that, over a period of 2 years, % of patients have improved symptoms with a variety of treatments.

Our results indicate that cultured autologous chondrocytes can be used to repair articular cartilage defects in the femorotibial joint and that this treatment restores the function of the joint by Cited by: A Cost-Effectiveness Analysis of Surgical Treatment Modalities for Chondral Lesions of the Knee: Microfracture, Osteochondral Autograft Transplantation, and Autologous Chondrocyte ImplantationCited by: The results suggest that transplantation of allogeneic chondrocytes cultured in Atelocollagen gel is effective in repairing an articular cartilage defect.

View Show abstract. Autologous chondrocyte transplantation (ACT), also referred to as autologous chondrocyte implantation (ACI), is a form of tissue engineering that creates a graft from a patient’s own cartilage cells to repair defects in the articular cartilage.

For first-generation ACI, the process involves removal, expansion (culture), and reimplantation of the. Jobanputra, P Parry, D Fry-Smith, A Burls, A.

Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: A rapid and systematic review. Health Technol Assess. Health Technol by: Smaller defects in specific locations may be treated with enhanced bone marrow stimulating techniques, autologous chondrocyte implantation (ACI), or osteochondral autograft transfer which may be completed through the arthroscope.

There is also a chapter for conservative treatments options and rehabilitation after cartilage repair. Autologous osteochondral grafting was found to be an effective technique for treating relatively young patients who had cartilage defects combined with ACL injury or.

Jobanputra P, Parry D, Fry-Smith A, et al. Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: A rapid and systematic review. Health Technol Assess. ;5(11) State of Minnesota, Health Technology Advisory Committee (HTAC).

Autologous chondrocyte implantation for chondral knee damage. Autologous Chondrocyte Implantation Page 2 of 3 Exclusion Criterion All other uses are considered experimental and investigational.

References: 1. Jobanputra P, Parry D, Fry-Smith A, et al. Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: A rapid and systematic review.

Health. Current cartilage regenerative therapies are not fully effective in treating osteoarthritis of the knee (OAK). We have developed chondrocyte sheets for autologous transplantation and tested these Cited by: 6. To critically analyze the existing literature relating to autologous chondrocyte implantation (ACI) and thereby to ascertain whether the technique is clinically effective and safe.

BurlsEffectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: a rapid and systematic review. by: Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: A rapid and systematic review.

Health Technol Assess. 5: 1 – King PJ, Bryant T, Minas by: Mosaicplasty consists in transplanting hyaline cartilage plugs taken from non-load-bearing sites. Autologous cartilage implantation (ACI) is an alternative to microfracture and mosaicplasty.

ACI leads to the synthesis of hyaline cartilage containing type II collagen. The first ACI procedure in a human patient was performed in Sweden in to Cited by:. Jobanputra P, Parry D, Fry-Smith A, Burls A. Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: a rapid and systematic review.

Health Technol Assess. ; 5 (11):1– [Google Scholar].Rehabilitation After Autologous Chondrocyte Implantation for Isolated Cartilage Defects of the Knee Anja Hirschmu¨ller,*y MD, Heiner Baur,z§ PhD, Sepp Braun,y MD, Peter C.

Kreuz,|| MD, PhD, Norbert P. Su¨dkamp,y MD, PhD, and Philipp Niemeyer,y MD, PhD Autologous chondrocyte implantation for treatment of isolated cartilage defects of the knee has become well by: repair articular cartilage defects, transplantations of various tissues or cells have been investigated both in animal and human models1.

To repair articular cartilage defects in humans, mosaic plasty2 (transplantation of multiple, small, autologous osteochondral grafts) and autologous cultured chondrocyte implantation3 are effective. However.